Features of taking Siofor 1000 tablets for weight loss

Excess weight is not decorative. When the body suffers from obesity, all organs receive a huge load, they work “for wear and tear”. Blood pressure, shortness of breath, arthritis, dizziness, decreased physical activity - this is just a small list of all the disadvantages of being overweight. A shapeless figure does not adorn women.

Although men are more lenient about their appearance, obesity still causes them no less harm than the fair sex. It is necessary to work comprehensively with excess weight. A special drug for weight loss - Siofor 1000 promotes rapid and painless weight loss, with minimal side effects. Why is Siofor 1000 so effective?

Unique composition

Physical exercise must be supported by the use of special medications, otherwise it will be very difficult for the body to cope with the processing of fat deposits. During weight loss, the heart pumps blood in an enhanced mode, the lungs work in “combat readiness” mode. Siofor 1000 is a popular hypoglycemic drug that is prescribed not only to obese people, but also to diabetics. Belongs to the group of biguanides.

The main active ingredient of Siofor 1000 tablets is metformin. It is prescribed to regulate glucose levels in diabetics who require constant use of insulin. It is advisable to take the drug Siofor 1000 when increased physical activity and diet do not bring the desired effect, and on the contrary, glycemia worsens.

The tablets do a good job of lowering blood cholesterol.

The drug has a complex effect on the body: it reduces absorption and production of glucose from the gastrointestinal tract. While taking Siofor 1000 tablets, insulin resistance decreases and the body becomes less sensitive to insulin.

Available in tablet form, but there are various variations:

1. Simple tablets;
2. Longer-acting tablets than regular tablets;
3. In a film shell;
4. With enteric soluble coating.

The tablets are produced with a notch for separation and a special snap-tab recess.

Instructions for use

To lose weight, it is recommended to take the drug according to the following regimen:

1. Every morning, take a 500 mg tablet before meals with a glass of purified water. During the course, you should adhere to a diet plan that includes low-calorie foods. If the diet remains the same, then the dosage is doubled, and the dose is divided into two times: morning and evening. After a week, the dose is increased to three tablets.
2. The Siofor 850 regimen involves taking 1 tablet once a day for two weeks. Then the dosage is increased to 2 tablets.
3. The Siofor 1000 regimen involves taking 0.5 tablets once a day. The dosage should be increased to 1 tablet 2 weeks after monitoring the level of insulin in the blood.

If you are planning heavy physical activity associated with training or work, it is better to postpone the use of the drug.

The course of use of Siofor should not exceed 3 months. The effect of the active component begins to weaken after prolonged use, so it is recommended to take a break.

The product will not be suitable for any person whose insulin levels are normal. In addition to the zero effect of losing weight, your health may worsen.

Pharmacodynamics

The main active component of Siofor 1000 is metformin hydrochloride.

The action of the tablets is determined by metformin:

• Antiglycemic effect;
• Decrease in basal, postprandial glucose concentration in plasma;
• Does not stimulate insulin production, does not lead to hypoglycemia;
• Reduces glucose production by suppressing glycogenolysis and glyconeogenesis;
• Increases muscle sensitivity to insulin, so glucose is better processed and absorbed in the periphery;
• Helps reduce the absorption of glucose in the intestines;
• It has a stimulating effect on intracellular glycogen synthesis by affecting glycogen synthetase;
• Strengthens the transport volume of currently known glucose membrane proteins that perform a transport function;
• It has a positive effect on lipid metabolism, reduces the concentration of total cholesterol, triglycerides, and low-density cholesterol.

  

Pharmacokinetics

Characteristics of the main active ingredient of Siofor 1000 for weight loss - metformin:

• After oral administration, it is adsorbed in the gastrointestinal tract. The maximum concentration in the blood is reached after 2.5 hours, and when taking the maximum dose does not exceed 4 mcg per 1 ml. During administration, absorption decreases and slows down;
• Distribution: the drug accumulates in the kidneys, muscles, liver, salivary glands and penetrates into red blood cells. Bioavailability in insulin-dependent adults who do not suffer from other diseases is in the range of 50-60%. Almost does not bind to blood plasma proteins. The average volume of distribution is at: 63-276 l;
• Excreted from the body through the kidneys: clearance is above 400 ml per minute. Half-life occurs in 6.5 hours. The clearance of metformin with a decrease in renal function decreases in proportion to the clearance of creatinine, because of this the half-life is significantly prolonged, and the concentration of the substance in the blood increases.

Contraindications to taking Siofor 1000 for weight loss:

1. For allergic diseases, high sensitivity to metformin hydrochloride and other substances included in Siofor 1000;
2. For complications due to diabetes, with increased blood sugar - hyperglycemia, blood oxidation due to the concentration of ketone bodies. Signs of this condition: abdominal pain, difficulty and increased breathing, strange smell from the mouth (smells like fruit);
3. It is not recommended to use Siofor 1000 for weight loss if you have liver or kidney diseases;
4. In acute conditions that lead to kidney diseases, for example: loss of fluid after severe vomiting, diarrhea; complex infectious diseases, poor blood circulation, if it is necessary to administer a contrast agent for x-ray or other studies;
5. For chronic diseases in acute form, which can lead to oxygen starvation, for example: heart failure, heart attack, obstructed blood circulation (state of shock), impaired pulmonary functionality;
6. In case of severe alcohol or drug poisoning;
7. During pregnancy, during breastfeeding.

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If any of the above diseases occur, you must immediately inform your doctor.

Contraindications and side effects

Siofor is a medication specifically intended for the treatment of diabetes (type 2), which has a weight loss effect. When using a drug for weight loss, remember that the drug has a number of restrictions, contraindications, and side effects that can negatively affect the condition of your body. Before taking Siofor to speed up the process of losing weight, consult an endocrinologist, carefully study the methods of use and instructions for the medicine.

Siofor contraindications:

• Insulin-dependent diabetes mellitus (type 1).
• Hypersensitivity.
• Kidney and liver dysfunction.
• Cardiac and respiratory failure.
• Severe infections.
• Operations, injuries.
• Tumor (benign, malignant) diseases.
• Diet less than 1,000 kcal/day.
• Chronic alcoholism.

The drug is prohibited during pregnancy, lactation, and is contraindicated for children. When you start taking the medicine, side effects are possible: digestive upset (nausea/vomiting/diarrhea), acute pain in the stomach, metallic taste in the mouth, allergic rashes. Dysfunction from the gastrointestinal tract disappears with time of addiction to the drug and does not require discontinuation of treatment. Symptoms of an overdose of Siofor are similar to food poisoning and are easily eliminated by taking a small portion of sweets.

How to take Siofor 1000?

Diet pills Siofor 1000 should be taken only under the supervision of a physician. If you have any questions, please contact your pharmacist or your doctor.

The dosage of the drug is determined for each patient individually based on the level of sugar in the blood, under the control of this indicator in the process of taking the tablets. This is very important when treating children, elderly patients and adolescents.

Siofor 1000 tablets are available with a coating. The dose of the active substance is at the level of 500 mg and 850 mg.

Taking Siofor 1000 tablets for adults:

• The standard starting dose is half a Siofor 1000 tablet. This corresponds to a dosage of 500 mg of metformin. The drug should be taken 2-3 times. per day. Reception 1 r. per day or with a dosage of 850 mg throughout the day is not recommended.
• Depending on the patient’s condition and blood sugar concentration, the doctor adjusts the dose after 10-15 days. Depending on the blood sugar level. A gradual increase in the dose helps to improve the tolerability of the tablets from the gastrointestinal tract. The usual dose after correction is 1 tablet of the drug Siofor 1000 with a coating 2 r. per day - this corresponds to 2000 mg of metformin per day.

Taking the drug Siofor by 1000 ten-year-old children and adolescents:

1. The usual starting dose is half a coated tablet, which corresponds to 500 mg of metformin. You need to take Siofor 1000 2-3 times. in a day. Taking tablets 1 r. during the day or 850 mg is not recommended.
2. After 10-15 days of taking the pills, the doctor makes changes to the dosage depending on the blood sugar level. With a gradual increase in dosage, the tolerability of the tablets from the gastrointestinal tract improves.

The usual dosage after adjustment is: 1 tablet, 1 r. per day - this corresponds to 1000 mg of metformin per day.

The maximum dosage of the drug is: 1 tablet Siofor 1000 with 2 r. per day - this corresponds to 2000 mg of metformin per day.

Siofor: varieties

Siofor is a biguanide drug that controls hypoglycemic processes in the body. Prescribed by doctors mainly to people with type 2 diabetes to stabilize blood sugar levels. The maximum concentration of the drug occurs two and a half hours after administration. But Siofor is also used for weight loss because it, by acting on the hormone insulin, helps reduce appetite.

Siofor oblong white tablets contain the active substance metformin. Depending on the amount of this substance, the medicine is divided into 3 types.

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The first is Siofor 500 . One tablet contains 500 mg of metformin hydrochoride. It also contains additional substances such as magnesium stearate, silicon dioxide, povidone and macrogol.

Siofor 850 contains, respectively, 850 mg of metformin and similar additional components.

Siofor 1000 has the highest concentration of the same active substance (metformin hydrochloride) - as much as 1000 mg per tablet.

The number of tablets indicated for use during the day depends on which drug you take.

Siofor is excreted from the body naturally (along with urine) approximately six and a half hours after administration. The active substance - metformin - actually does not remain in the body after the half-life. The need to take any type of drug - Siofor 500, Siofor 850 or Siofor 1000 - can in no case be arbitrary and is determined only by the doctor.

Possible side effects

Taking Siofor 1000 for weight loss can cause certain side effects - this is typical for almost all medications. Side effects do not necessarily develop in all patients.

The following side effect occurs very often:

1. Vomit;
2. Nausea;
3. Diarrhea;
4. Abdominal pain;
5. Loss of appetite.

Such manifestations are possible at the very beginning of therapy, and in most cases they resolve spontaneously. To prevent them, it is worth distributing the drug Siofor 1000 several times (2-3 times) during the day during or after meals. If there are no symptoms, you should consult a doctor.

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The following side effects often occur:

• Change in taste, but rare;
• Serious metabolic disorders in the body: severe oxidation of blood with lactic acid - the so-called “Lactic acidosis”. This effect manifests itself as nausea, diarrhea, and abdominal pain. Then, within a few hours, muscle pain, spasms, disturbances, increased breathing, clouding of consciousness to a state of coma may occur. If you suspect lactic acidosis, you should immediately consult a doctor and then stop taking Siofor 1000;
• Decreased blood levels of vitamin B12 due to reduced absorption. It is caused due to a certain form of red blood cell deficiency called megaloblastic anemia;
• Skin rashes, itching, redness.

  

The following side effects may occur with unknown frequency:

• Unusual liver test results, liver inflammation with or without hepatitis. This occurs after stopping taking Siofor 1000 orally.

Ten year olds and teenagers:

• There is not enough information today about side effects after taking Siofor tablets by 1000 ten-year-old children and adolescents. The recorded side effects are similar in severity and nature to the consequences in adults.

If side effects become more frequent, you should immediately consult your doctor.

Side effects and overdose

These include:

• From the stomach and digestive tract - diarrhea, vomiting, anorexia, loss of appetite, stomach pain, lack or decreased appetite, metallic taste in the mouth; It is worth noting that these negative phenomena are reversible and during therapy they gradually disappear
• In rare cases, megaloblastic anemia (acute lack of cyanocobalamin and folic acid in the patient’s body) may occur, which is easily relieved by additional intake of the missing vitamins
• From the skin - allergic rashes and other external reactions (urticaria, itching, pain, redness)
• Lactic acidosis.

In terms of the occurrence of severe hypoglycemia, the medication is not dangerous, since clinical trials confirmed that a single excess of the daily dosage at one time by more than 30 times did not cause severe disturbances in blood glucose levels. True, another side effect occurs in case of overdose - lactic acidosis, which can cause negative phenomena in the form of diarrhea, vomiting, rapid breathing, and loss of performance. Hemodialysis is needed. Often the syndrome can be stopped with a large portion of fast carbohydrates.

Overdose

All patients should take Siofor 1000 weight loss tablets as directed by their physician. It is not recommended to exceed the norm on your own. According to studies, hypoglycemia due to an overdose of the drug is unlikely.

Even if 85 g of the main active ingredient was taken, only laccidosis can develop - a dangerous condition for the patient. The first symptoms of laccidosis:

1. Diarrhea;
2. Dizziness;
3. Tachypnea;
4. Abdominal pain;
5. Myalgia;
6. High body temperature;
7. Coma;
8. Impaired consciousness.

If the patient experiences the above conditions, it is necessary to urgently take him to the hospital for medical care. It is impossible to cope with the consequences of lactic acidosis at home.

To effectively remove excess metformin and lactate from the body, hemodialysis should be performed.

Interaction with other drugs

If Siofor 1000 tablets are used together with other drugs, the following effects may develop:

• With donazol - development of a hyperglycemic effect;
• Together with drugs containing nicotinic acid, thyroid hormones, phenothiazine derivatives, glucagon, oral contraceptives, epinephrine, the concentration of glucose in the blood plasma may increase;
• With nifedipine - increases adsorption, maximum concentration in the blood plasma, prolongs the withdrawal of metformin;
• With cationic agents secreting in the tubules: vancomycin, triamterene, ranitidine, procainamide, amiloride, morphine, quinine, quinidine. With long-term use of the drug Siofor 1000, an increase in the concentration of metformin in the blood is possible;
• With cimetidine: the elimination of metformin is slowed down, resulting in an increased risk of developing lactic acidosis;
• With furosemide: max concentration and half-life increase;
• Indirect anticoagulants: possible weakening of effect;
• With salicylates, acarbose, sulfonylurea derivatives, insulin, the hypoglycemic effect may be enhanced;
• With angiotensin-converting enzyme inhibitors, as well as other antihypertensive drugs: a decrease in the concentration of glucose in the blood is possible.

Features of taking Siofor 1000 tablets for weight loss

The accumulation of metformin can cause lactic acidosis, a rare pathological condition that is associated with an increase in the concentration of lactic acid in the blood.

Based on patient reviews, one can judge the development of this condition in patients who suffer from diabetes mellitus with renal failure and who take metformin.

In order to prevent lactic acidosis, it is worth considering all available risk information, for example, excessive alcohol consumption, prolonged fasting, liver failure, ketosis, uncontrolled diabetes, as well as any patient condition associated with hypoxia.

If the suspicion of the development of lactic acidosis is confirmed, then the drug Siofor 1000 is stopped and the patient is hospitalized. Metformin is excreted through the kidneys, so before starting to take the tablets, it is necessary to determine the concentration of creatinine in the blood.

Particular caution should be exercised if there is a risk of renal dysfunction, for example, at the very beginning of treatment with non-steroidal anti-inflammatory drugs, diuretics or antihypertensive drugs.

Two days before and two days after an x-ray with intravenous administration of iodine-containing substances, instead of the drug, another drug is taken to lower blood glucose (for example, insulin).

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A couple of days before surgery under general, epidural, or spinal anesthesia, the drug is stopped. Treatment with the drug continues after the resumption of oral nutrition or no earlier than 2 days after surgery, but with the condition of normal renal function.

Siofor 1000 diet pills cannot replace physical exercise.

While taking the pills, patients need to combine various types of therapy as recommended by their doctor. During treatment, patients should follow a diet with a balanced intake of carbohydrates. If you are obese, it is recommended to follow a low-calorie diet.

During treatment, it is necessary to carry out the full range of standard laboratory tests as for diabetes mellitus. Before prescribing the drug to children under 18 years of age, the diagnosis of type 2 diabetes mellitus must be confirmed.

If you take Siofor 1000 in combination with sulfonylurea derivatives or insulin.

Taking Siofor 1000 tablets and the ability to operate complex mechanisms and vehicles

When the drug Siofor 1000 is combined with other medications, hypoglycemic conditions develop. Therefore, patients need to exercise caution when operating complex machinery and vehicles, as well as during potentially hazardous activities.

Taking the pills itself does not lead to a decrease in blood sugar - hypoglycemia, and therefore does not affect the ability to drive vehicles or operate highly complex mechanisms.

But with the simultaneous use of several medications for diabetes, for example, insulin, repaglinide, sulfonylurea, this ability may be impaired due to a decrease in blood sugar levels.

Advantages and disadvantages

Advantages:

1. Suppresses appetite (sometimes apathy towards food occurs).
2. Strong physical activity is not required ; you can get by with walking and gymnastics.
3. Quick results.
4. Opportunity to change your diet.

Flaws:

1. The drug is taken under strict medical supervision.
2. At normal levels of insulin in the blood, the drug is ineffective.
3. Contraindications.

Under what conditions can Siofor 1000 tablets be stored?

The drug must be stored in a special place out of reach of children. If tablets are prescribed to children, then the doctor and parents must monitor the intake. Do not use the drug after the expiration date, which is indicated on the blister and pack. The expiration date ends on the last day of the specified month. No special conditions are required for storing Siofor 1000 tablets.

Siofor 1000 is a popular remedy for weight loss. The main purpose of the drug is the treatment of type 2 diabetes mellitus. The main purpose of Siofor 1000 tablets must be taken into account; weight loss is an indirect effect. Doctors do not recommend starting to take diet pills on your own.

The instructions say that without the supervision of a qualified specialist, unpredictable consequences may occur for the body. For example, an effective remedy for combating type 2 diabetes has a depressing effect on the kidneys.

If the patient has not undergone a specialized examination and it is not known what condition the kidneys are in, then the patient’s health is in great danger . It is necessary to help the body achieve its goal, and not hinder it.

Analogs

Glucophage

Merck Santé, France

The average cost in Russia is 110 rubles per package.

Glucophage is a well-known French generic, one of the analogues of Siofor 850. It is also on sale in dosages of 500 and 1000 mg. The largest dosage form has an oval tablet shape, while the rest are round. With the help of glucophage, obesity associated with type 2 diabetes mellitus can be treated. The medicine is distinguished by the fact that it is produced by a serious French pharmacological company, it is better tolerated than domestic analogues, but it also costs a little more.

Pros:

• Effective medicine
• Foreign analogue.

Minuses:

• Also has many side effects
• It may not fit.

Gliformin

Akrikhin, Russia

The average cost of the medicine is 106 rubles per package.

Gliformin is a good domestic generic that can always replace any foreign analogue. Just like all other analogues, gliformin is a worthy substitute for any industrial metformin. According to reviews from those who have lost weight, and from everyone who drank it, it is no worse, and the price will be better. Release form: tablets of 500, 800 and 1000 mg. In this case, the drug differs in that it has a slightly non-standard dose distribution among tablets. If in other forms of release it is 850 mg, then here it is 800. Like other generics, gliformin has the same negative effects and pharmacological properties.

Pros:

• Effective Russian-made generic
• Relatively inexpensive.

Minuses:

• Side effects may occur
• Not suitable for everyone.

Reviews

Lyudmila, 37 years old, St. Petersburg » I bought Siofor 1000 for weight loss, it helped a lot. In addition to the pills, I was on a low-calorie diet and did 3 p. 1.5 hours of physical exercise per week. Before this, just physical exercise and diet did not help me. Against the background of Siofor, my complexion and skin condition in general have improved. I couldn’t do without consulting a doctor; I took tests to check the condition of my kidneys and sugar levels. I turned out to have a tendency towards diabetes, my sugar level was not critical, but later diabetes could well have developed. It’s good that I noticed the excess weight in time and took action.”

Olga, 45 years old, Moscow “I have been taking diet pills for a long time, I already have some experience. Most drugs have strong side effects. Siofor has almost no side effects compared to regular diet pills. Among the shortcomings, I would note the expensive price of Siofor 1000, the rest deserves high praise. In two months I managed to lose 9 kg, I finally put on my favorite dresses. All my clothes fit perfectly on me. I took sugar tests beforehand, the drug helps. I'm happy with the result."