Goldline diet pills: review of an alternative way to lose weight

Compound

The drug contains 10 or 15 mg of sibutramine as an active substance, as well as microcrystalline cellulose (Cellulose microcrystalline), lactose (Lactose), colloidal silicon dioxide (Silicium dioxide colloidal), magnesium stearate (Magnesii stearas).
The composition of the Goldline 10 mg capsule body includes: gelatin (Gelatine), titanium dioxide (Titanium dioxide), sodium lauryl sulfate (Sodium lauryl sulfate), dyes (sunset yellow and quinoline yellow).

To make the body of Goldline 15 mg capsules, the following are used: gelatin (Gelatine), titanium dioxide (Titanium dioxide), sodium lauryl sulfate (Sodium lauryl sulfate).

Composition of the capsule cap: gelatin (Gelatine), titanium dioxide (Titanium dioxide), sodium lauryl sulfate (Sodium lauryl sulfate), dyes (diamond blue and acid fuchsin D&C33).

Pharmacodynamics and pharmacokinetics

Goldline is a centrally acting agent for the treatment of obesity.

Its active substance sibutramine is a prodrug that exhibits its pharmacological properties in vivo due to primary and secondary amines - products of drug metabolism, which are characterized by the ability to inhibit the reuptake of monoamines (mainly serotonin and norepinephrine ).

The use of the medicine allows you to increase the feeling of satiety, reduce the need for food, and also increase thermal production. These effects are achieved by increasing the content of neurotransmitters in synapses and, consequently, increasing the activity of central serotonin (type 5-HT) and adrenergic receptors .

Sibutramine also has the ability to act on brown adipose tissue through indirect activation of β3-adrenergic receptors .

Weight loss, in turn, is accompanied by an increase in serum concentrations of high-density lipoproteins and a decrease in the concentrations of low-density lipoproteins, total cholesterol , uric acid and triglycerides.

Neither sibutramine nor its metabolic products:

• do not inhibit the enzyme monoamine oxidase (MAO);
• do not affect the release of monoamines ;
• do not have an affinity for a sufficiently large number of neurotransmitter receptors (including serotonin types 5HT1-, 5HT1A-, 5HT1B-, 5HT2A-, 5HT2C-; adrenergic beta 1, 2 and 3, as well as alpha 1 and 2; dopamine D1 and D2; benzodiazepine , muscarinic , NMDAR, histamine H1-).

After taking p/os, sibutramine is absorbed from the digestive tract by at least 77%. During the first passage through the liver the substance is metabolized under the influence of isoenzyme to mono- and didesmethylsibutramine , which are its active metabolites .

The substance is quickly distributed throughout the tissues. protein binding rate for sibutramine is 97%, for its metabolites - 94%.

T1/2 of sibutramine - 1.1 hours, metabolites - 14 and 16 hours (for mono- and didesmethylsibutramine, respectively). After hydroxylation and conjugation, active metabolites are biotransformed into inactive ones, which are eliminated mainly by the kidneys .

Action

Goldline Plus has a fairly strong effect on the patient's body. Reviews from people losing weight confirm that the effect can be observed after 2 weeks of regular use. Thanks to the action of sibutramine, satiety hormones are produced. A person eats less food without feeling hungry.

This often occurs in the first few days after starting a diet. Sibutramine acts due to its primary and secondary metabolic products. This means that the substance itself is not able to control the brain centers, but its breakdown products affect the brain and hormonal levels.

After the capsule penetrates the digestive tract, its active processing begins and the ingredients enter the blood. It is worth noting that microcrystalline cellulose complements the action of the main component, helps stimulate the intestines and remove harmful components, toxins, and waste from it.

This improves the absorption of vitamins and minerals from food and increases the amount of energy produced after food processing. Additionally, the product reduces the level of bad cholesterol and uric acid in the blood. The bioavailability of the product after taking it is approximately 75-77%.

At the same time, sibutramine binds well to plasma proteins, which provides a pronounced therapeutic result. It is also important to know that the metabolites of this component are almost completely absorbed in the body, and their bioavailability reaches 95%. A small amount of unprocessed substance is excreted in urine and feces within 2 hours after the last dose.

Metabolic products are evacuated within 16-17 hours. In patients with pathologies of the liver, stomach and intestines, as well as kidney damage, the elimination period is extended by several hours. The bulk of the components are evacuated by the kidneys, so it is not only inflammation or failure of the paired organ that provokes a slowdown in this process.

Any disorder of the urinary system can affect it. The drug does not accumulate in the body, despite its rapid distribution in tissues and organs.

Contraindications

The drug has a number of contraindications, including:

• hypersensitivity to its components;
• the patient has organic causes of obesity;
• mental illness;
• congenital heart defects;
• bulimia nervosa or anorexia nervosa ;
• Tourette's disease;
• decompensated heart failure;
• arrhythmia and tachycardia ;
• obliterating atherosclerosis of the arteries of the lower extremities;
• cardiac ischemia;
• cerebrovascular diseases (including, but not limited to, transient cerebral circulatory disorders and strokes );
• arterial hypertension (when blood pressure is more than 145/90 mm Hg);
• severe kidney or liver dysfunction
• pheochromocytoma;
• hyperthyroidism;
• prostate adenoma , which is accompanied by the appearance of residual urine;
• angle-closure glaucoma;
• taken in combination with MAO inhibitors or other drugs that affect the central nervous system (and also if less than 14 days have passed since their discontinuation);
• simultaneous use of other anorekisgenic drugs ;
• established alcohol, drug or drug addiction;
• age over 65 years and under 18 years.

It is recommended to prescribe Goldline with caution to patients with mild to moderate disorders of liver and/or kidney function ; neurological disorders (including mental retardation and increased convulsive activity, including a history), motor or verbal tics (including a history); chronic circulatory insufficiency, coronary artery diseases (including a history); cholelithiasis , history of arrhythmia controlled arterial hypertension , as well as if hypertension is noted in the anamnesis.

Side effects

The most common side effects associated with the use of the drug Goldline occur in the first weeks of treatment (they are usually observed during the first month). Over time, their severity and frequency of occurrence decrease.

In general, side effects associated with taking the drug do not pose a threat to health and are reversible.

The most common adverse events (occurring in at least every 10 patients):

• insomnia;
• loss of appetite;
• feeling of dry mouth;
• constipation.

Sometimes (occur with a frequency of 1-10%) the following may appear:

• headache;
• increased anxiety;
• dizziness;
• paresthesia;
• vasodilator effect (including hyperemia of the skin);
• moderate increase in heart rate (on average 3-7 beats per minute);
• tachycardia;
• increased blood pressure (at rest, they increase by an average of 1-3 mm Hg);
• heartbeat;
• exacerbation of hemorrhoids ;
• nausea and change in taste;
• increased sweating.

At the initial stages of treatment with Goldline, a more significant change in blood pressure and pulse rate is possible (usually such phenomena are observed in the first 4-8 weeks of taking the drug).

In isolated cases, such clinically significant side effects were recorded as: skin itching, development of flu-like syndrome , dysmenorrhea , back and abdominal pain, edema, paradoxical increase in appetite, drowsiness, bleeding, convulsions, increased thirst, runny nose, depression, mood lability, irritability , nervousness, anxiety, acute interstitial nephritis , rheumatic purpura , transient increase in the activity of liver enzymes in the blood , thrombocytopenia .

One patient with schizoaffective psychosis , which most likely existed before the start of drug treatment, developed acute psychosis .

The body's response to stopping Goldline, which manifests itself in the form of headaches and increased appetite, rarely develops.

evidence that withdrawal symptoms , withdrawal symptoms , or mood disturbances may occur after stopping treatment.

Goldline tablets: instructions for use

How to take Goldline capsules

The starting dose of the drug is 10 mg/day. If the expected effect is not observed when using it (in situations where body weight decreases by less than 2 kg during a month of treatment), as well as if the drug is well tolerated, the dose is increased to 15 mg/day.

If there is no effect even when using a higher dosage (weight decreases by less than 2 kg per month), treatment with sibutramine is stopped.

In patients who do not adequately respond to the prescribed treatment, that is, within three months their weight decreases by less than five percent of the original, the duration of use of Goldline should not exceed 3 months.

The maximum duration of treatment is two years. This is due to the lack of reliable data on the safety and effectiveness of using sibutramine over a longer period of time.

You should not continue taking the drug if, after achieving weight loss during further treatment, the patient again gains three (or more) kilograms.

It is considered advisable to supplement therapy with physical activity and diet. Training should be carried out under the supervision of a specialist who has sufficient practical experience in treating people suffering from obesity.

Instructions for Goldline Light

Goldline Light is a drug produced by the pharmaceutical company Izvarino Pharma LLC.

The official website of the tablets states that this product is not a drug and is used by overweight people who actively use physical activity to lose weight, as a dietary supplement.

The daily dose of the drug contains 48 mg of lipoic acid and 360 mg of L-Carnitine (vitamin BT).

In combination with moderate physical activity and a low-calorie diet, weight loss with the use of the product increases by 22% with regular use for six months. In this case, the concentration of α-lipoic acid should be at least 1% of the weight of the total amount of food eaten.

With moderate intensity physical activity, fat burning increases by 36-55%.

In addition, α-lipoic acid is a good antioxidant , which, due to its ability to dissolve in both non-polar and polar solvents, exhibits its properties both in cells and in the extracellular space.

cATP-dependent protein kinase which influences human eating behavior , resulting in increased energy expenditure and decreased food consumption.

The effect of using the drug is dose-dependent.

In accordance with the instructions, take 1 or 2 Goldline Light capsules approximately 15-20 minutes before the start of training and then within 60-90 minutes after it ends.

Lipoic acid is a medication prescribed for cirrhosis or fatty liver , hepatitis A , and chronic hepatitis . Lipoic acid is not available without a prescription because it often causes the following side effects:

• severe allergic reactions (this may be itching, urticaria or systemic allergic reactions);
• dyspepsia.

At the same time, in the instructions supplied with the Goldline Light dietary supplement, the manufacturer does not warn about the possibility of developing such side effects.

You should also remember that taking capsules should not be combined with taking any multivitamin complexes , drugs for the treatment of anemia and other drugs that contain calcium, potassium, iron or magnesium ions.

Dosage

The medicine is taken in the morning, once on an empty stomach or during breakfast. Do not chew the capsules, wash them down with plenty of water.

Dose:

• 10 mg – initial dose;
• 5 mg – initial dose if poorly tolerated;
• 15 mg – dose taken after a month, if weight loss is insufficient (less than 5%).

The total maximum duration of treatment is 2 years or less. If there is an abrupt increase and decrease in weight (within 3 kg within 3 months), treatment with Goldline is considered ineffective and is discontinued.

In case of an overdose of the drug, symptoms such as increased blood pressure, increased heart rate, and headache may appear. Stop taking the drug, perform gastric lavage, and use sorbents to reduce the concentration of Sibutramine in the stomach.

Overdose

To date, there is not enough data on sibutramine . An increase in the severity of adverse reactions is considered the most likely.

If a suspected overdose of Goldline occurs, you should notify your doctor.

There are no specific antidotes or special treatment. It is recommended to provide the patient with free breathing and keep the condition of the cardiovascular system . Further therapy is symptomatic.

Timely intake of activated carbon gastric lavage procedure can reduce the absorption of the drug in the intestinal tract .

Patients who have high blood pressure may be prescribed β-blockers .

The effectiveness of hemodialysis or forced diuresis has not been established.

Interaction

The simultaneous use of sibutramine with inhibitors of microsomal oxidation (including the CYP3A4 isoenzyme) increases the plasma concentration of its metabolites, heart rate and provokes a clinically insignificant increase in the QT interval.

The metabolism of sibutramine is accelerated when used in combination with phenytoin , dexamethasone , carbamazepine , rifampicin , phenobarbital and macrolide antibiotics .

Serious interactions are possible in the case of simultaneous administration of several drugs that increase the concentration of serotonin in the blood.

In rare cases, serotonin syndrome develops when sibutramine in combination with:

• serotonin reuptake inhibitors , which are used to treat depression and anxiety disorders;
• certain antimigraine drugs (for example, dihydroergotamine or sumatriptan );
• antitussives ( dextromethorphan );
• opioid analgesics ( fentanyl , pentazocine , pethidine ).

Sibutramine has no effect on the action of oral contraceptives .

With simultaneous use of sibutramine with ephedrine , pseudoephedrine , phenylpropanolamine and combination drugs containing these substances, the risk of increased blood pressure and heart rate increases.

The substance does not enhance the negative effects of ethanol, however, drinking alcohol during treatment with Goldline reduces the effectiveness of dietary measures.

Drug interactions

The medication is strictly contraindicated in combination with other weight loss products. It is also not taken at the same time as brain-stimulating medications. It is strictly contraindicated to combine the product with barbiturates, antibiotics from the macrolide group, as well as corticosteroids and antitussive medications.

It is allowed to take Goldline Plus in combination with vitamin complexes and immunostimulating agents. It is not recommended to use drugs that contain ethyl alcohol during the treatment period, as they weaken the effect of the drug. The same rule applies to alcoholic beverages.

It is noted that Goldline Plus does not affect the effectiveness of contraceptive drugs, and they, in turn, do not weaken the effect of the weight loss product.

special instructions

Goldline diet pills are prescribed only in cases where all other measures aimed at weight loss are ineffective. Treatment should be carried out under the supervision of a specialist who has sufficient experience in weight correction for obesity as part of complex treatment (including physical activity, review of diet, habitual lifestyle, diet).

The period of taking Goldline at a dose of 15 mg should be limited in time.

In the first 8 weeks of treatment, heart rate and blood pressure should be monitored every 2 weeks. After this time, monitoring is carried out once a month.

For patients with arterial hypertension (when the pressure is at the level of 145/90 mm Hg), blood pressure and heart rate are recommended to be monitored more often and more carefully. If the pressure rises above the specified values ​​2 times, treatment with Goldline is stopped.

The appearance of chest pain, swelling of the legs, and progressive dyspnea may indicate the development of pulmonary hypertension (such conditions require consultation with a doctor).

Women of childbearing age should use effective contraception throughout the entire course of use.

Sibutramine has the ability to reduce salivation, cause a feeling of discomfort in the oral cavity, provoke the development of caries and periodontal , thrush .

During the treatment period, you should refrain from performing work that could potentially threaten your health and life, as well as from driving a car.

What does a course of treatment with Golden Slim Pills phytocapsules provide for weight loss?

Taking tablets in the recommended dose promotes weight loss in people with any degree of obesity and overweight. The capsules have an excellent effect and do not have any negative effect even on the body of people suffering from a whole “bouquet” of concomitant pathologies. To obtain the desired result, strict adherence to doses is required, which should not be exceeded.

Vegetable capsules:

1. Strengthen metabolism, activate metabolic processes.
2. Restores proper functioning of the gastrointestinal tract.
3. Normalize intestinal microflora.
4. Prevents the formation of a layer of fat under the skin.
5. Eliminate visceral obesity.
6. Accelerate blood circulation.
7. Cleanses blood vessels.
8. Have a beneficial effect on the functioning of the heart muscle.
9. Improves the digestion process.
10. Improves the health of the body as a whole.

Thanks to phytocapsules, it is possible to neutralize cravings for harmful foods, reduce the feeling of hunger, reduce the number of meals, reduce portions of dishes, and reduce the calorie content of food.

The inclusion of valuable natural ingredients in the pills allows obese patients to maintain a feeling of fullness for a long time and not have to constantly snack, especially at night. In this way, high results and a clear and long-term prognosis can be guaranteed. According to the manufacturers, the lost kilograms do not return after completing the therapeutic course.

During pregnancy

The category of action on the developing fetus in accordance with the FDA classification is C. This means that animal studies have established a negative effect of the drug on the fetus, but strictly controlled studies of the use of the drug during pregnancy in humans have not been conducted.

It has also not been established whether sibutramine or its metabolites can pass into breast milk.

This excludes the possibility of using the drug by pregnant women and during breastfeeding.

Safety of Golden Slim Pills for weight loss

The herbal remedy, made entirely from natural raw materials, has undergone multi-stage rigorous testing. As a result of research, high therapeutic efficacy and complete safety for the body have been fully confirmed.

The natural product has received permission for widespread use and the required certificate. The weight loss product fully meets accepted international quality and safety standards.

Reviews about Goldline

Comments and reviews from those losing weight about Goldline 15 mg and 10 mg are quite contradictory. Some note the high effectiveness of the product (some women claim that by taking capsules for weight loss, they lost 7-8 kg in 3-8 weeks), while others say that taking the drug did not give them the desired result, but only provoked a lot of unpleasant symptoms ( pressure surges, headaches, dizziness, weakness, etc.).

In addition, in some reviews of Goldline diet pills, women complain that after stopping taking the capsules, their appetite noticeably increased, and the lost pounds returned almost immediately.

Doctors in reviews of Goldline tablets write that sibutramine is a potent substance that can be sold in pharmacies only with a prescription. It has quite a lot of contraindications and often provokes side effects.

Thus, they recommend taking the drug for weight loss only after consultation with a specialist and a thorough assessment of your health.

The use of the drug is advisable for obesity (that is, when the patient’s BMI is more than 30 kg/sq. m, in exceptional cases - at least 27 kg/sq. m) and only in the absence of endocrine diseases , heart and vascular , mental disorders and certain individual indicators that can be identified by the attending physician.

Only the attending physician can select the optimal dosage regimen (15 or 10 mg) and determine how long the treatment will be.

Often among reviews of Goldline there are also reviews of Goldline Light. Unlike Goldline, it is not a medicine, but a dietary supplement. As noted by women and girls who have taken the drug, the effect of its use is noticeable only if a low-calorie diet is followed and a sufficient level of physical activity is provided.

Simply taking capsules will not help you lose weight.

Indications for use

• Treatment of nutritional obesity with a BMI over 30 kg/m2;
• Relief of risk factors associated with excess weight in non-insulin-dependent diabetes mellitus and dyslipidemia.

The drug Goldline is used exclusively on the recommendation and under the supervision of the attending physician, as an element of complex therapy. Obesity therapy includes changes in diet and optimal physical activity. The use of the drug makes it possible to rebuild eating habits and lifestyle. Sustained habit changes will help maintain the results achieved during therapy. Otherwise, after discontinuation of the drug, a repeated increase in body weight will occur.

Goldline price

Price of diet pills in Russian pharmacies:

• from 1000 rub. per capsule 10 mg No. 30;
• from 1560 rub. per capsule 10 mg No. 60;
• from 1450 rub. per capsule 15 mg No. 30;
• from 2300 rub. per capsule 15 mg No. 60;
• from 2950 rub. for capsules 15 mg No. 90.

Price Goldline Light - from 450 rubles. for package No. 30, from 700 for package No. 60. In Ukraine, the price of Goldline Light No. 90 is 735 UAH.

The tablets are available with a prescription. If desired, they can be ordered online without a prescription. In large cities (for example, Krasnoyarsk, Moscow or Yekaterinburg), online pharmacies offer to buy Goldline with home delivery.

• Online pharmacies in RussiaRussia

ZdravCity

• Goldline Plus capsules 15 mg + 153.5 mg 60 pcs. Izvarino Pharma LLC
  RUB 3,747 order
• Goldline Plus capsules 15mg+153.5mg 90 pcs. Izvarino Pharma LLC

  RUR 5,029 order

• Goldline Plus capsules 15mg+153.5mg 30 pcs. Izvarino Pharma LLC

  RUR 2020 order

• Goldline Plus capsules 10mg+158.5mg 60 pcs. Izvarino Pharma LLC

  2150 rub. order

• Goldline Plus capsules 10mg+158.5mg 30 pcs. Izvarino Pharma LLC

  RUB 1,368 order

Goldline

Active substance:

Sibutramine*

Pharmgroup:

Appetite regulators

Average price in pharmacies