What are the benefits of Resveratrol? Reviews and instructions for use

Resveratrol is a substance that has a pronounced antibacterial and antifungal effect. In the scientific literature, such protective substances are called “phytoalexins.” Resveratrol is a natural component produced by some plants. Clinical studies are currently underway to identify its activity in the human body. Many experiments have been successful, and resveratrol is approved for use by humans. Scientists have achieved great success in experiments on rats: resveratrol acts as an effective antioxidant, antitumor, antiviral and antifungal agent in relation to rodent organisms.

Resveratrol: in products

The list of foods that contain resveratrol is small. The source of this substance is plants. The most resveratrol is found in the seeds of dark grapes, although small amounts are also found in the berries. In general, this substance is found in the skins of most vegetables and fruits, and it is also present in peanuts and cocoa.

Resveratrol: in red wine

resveratrol content is red wine. Scientists believe that the fermentation process increases the concentration of this beneficial substance. We cannot forget about the so-called “French phenomenon”: the French love to eat tasty and fatty foods. But, despite this diet, they practically do not suffer from cardiovascular diseases. We can thank resveratrol from red wine, the favorite drink of the French, for such indicators.
The useful substance cleanses blood vessels and reduces cholesterol levels in the blood, thereby preventing the development of vascular diseases.

Resveratrol - what is this substance?

Resveratrol is a plant toxin - a natural phytoalexin that is released by some plants during stress. Fungal or mechanical damage can trigger the release of phytoalexin.

That is, resveratrol is released by the plant in cases where it is one step away from death. And this is done for the banal purpose of survival. This substance is produced by plants in response to any damage, it helps the plant survive and is responsible for its immunity.

This is interesting!

Research has proven that resveratrol is capable of prolonging the life of living beings (scientists have observed fish, worms, yeast, and fruit flies). The lifespan of fish after using this substance increased by 59%.

Resveratrol: properties

Studies have found that resveratrol has a wide range of beneficial properties. Experiments conducted on rats showed very good results, but with the human body the situation is somewhat different: resveratrol is half as effective, but even to this extent it is much more effective than other similar substances.

1. Antitumor and antioxidant - the substance actively kills cancer cells and cleans cell membranes. Resveratrol more effectively directly, i.e. in those places with which it comes into contact, therefore it is advisable for them to treat skin cancer and tumors in the gastrointestinal tract. Another antitumor agent of plant origin, graviola, acts similarly.
2. Anti-inflammatory – prevents inflammatory processes in various tissues of the body, including the joints, in which case resveratrol acts similarly to methylsulfonylmethane and quercetin.
3. Antiviral and antibacterial - resveratrol destroys influenza viruses, simple types of herpes and many respiratory viruses. The substance also prevents bacteria from multiplying: chlamydia, yersinia and Pseudomonas aeruginosa.
4. Antidiabetic – lowers blood sugar levels and improves overall health. Although the most well-known fighters against high blood sugar are licorice root and gymnema, resveratrol is no less effective.
5. Cardioprotective – protects the heart and blood vessels from premature aging, reduces the risk of developing cardiovascular diseases.

Interesting facts about red wine

This is interesting!

It has long been noted that residents of France are less likely than others to die from diseases associated with blood vessels and the heart, as well as from tumors of malignant origin.

This phenomenon is called the “French paradox” in the world.

To these indisputable facts, scientific luminaries of the world answer that the whole point is that the inhabitants of France regularly drink red wine. It is this noble drink, according to scientists, that is the cause of this very “French paradox”.

Red wine contains a large amount of resveratrol, and this substance prevents the occurrence of dangerous diseases.

Therefore, for preventive purposes, you can drink a little red wine for dinner.

Resveratrol: application

Currently, resveratrol is quite widely used in the treatment of certain diseases. Resveratrol is considered one of the best antioxidants, so it is used to maintain overall body tone and prevent the aging process. Doctors recommend taking medications with resveratrol to patients with diabetes mellitus and atherosclerosis, as well as those who have suffered heart attacks and strokes. Resveratrol regulates fat metabolism and can be taken additionally during weight loss. This substance has a very good effect on arthritis, rheumatism and other joint ailments: it is used as an anti-inflammatory and analgesic. drink resveratrol to improve brain activity and memory.

Doctors' opinions on resveratrol

Unfortunately, leading doctors cannot come to a consensus on the effectiveness of a natural antioxidant. Accordingly, doctors' reviews vary greatly. Some actively use phytoalexin in their medical practice. For example, one leading New York City doctor recommends taking resveratrol supplements as a contraceptive.

But there are also many negative reviews about this substance among doctors. One of the skeptics of resveratrol is Richard Semba, who conducted experiments on his elderly patients. Semba gave his test subjects antioxidant supplements over a long period of time and found that it had no effect on their life expectancy.

Let's hope that in the near future, thanks to the successful use of phytoalexin, the world's leading doctors will come to a common, concrete opinion. But today, research continues, during which scientists continue to identify the unique properties of the substance.

Resveratrol: in cosmetology

Resveratrol is widely used in cosmetology, mainly due to its antioxidant properties. Resveratrol protects the skin from free radicals, harmful UV rays, stimulates collagen production and prevents skin aging. Resveratrol of oily skin prone to acne and inflammation : it destroys bacteria and relieves inflammation. It is included in modern cosmetics under the same name or trans-resveratrol .

How does resveratrol help us?

It reduces inflammation in our body and also affects hormone synthesis, blood flow and fat deposits. Scientists have found that the effects of resveratrol are as follows:

1. Reduces the production of sphingosine kinase and phospholipase D - 2 molecules that provoke inflammatory processes. Studies have revealed the ability of the substance to suppress the spread of cyclooxygenase enzymes that damage body tissue. Our bodies can produce inflammation to fight off bacteria and viruses, but chronic inflammation is not normal.
2. It has a beneficial effect on the growth process of vascular endothelium. In other words, it helps restore damaged blood vessels.
3. Reduces insulin content, which allows you to maintain youth, normal weight longer and prevent the development of diabetes. In the laboratories of Sirtris Pharmaceuticals, scientists found that taking resveratrol also reduces glucose levels. And this is very useful for those who care about their body and health.
4. Since resveratrol regulates the release of pro-inflammatory molecules, it can help prevent autoimmune diseases. It has a beneficial effect on the intestinal microflora, affects the proliferation and differentiation of stem cells.
5. Normalizes blood flow, preventing arteries from being damaged. Helps activate the barrier functions of the brain and reduces the possibility of Alzheimer's disease. It is likely that the drug can also minimize the risk of ischemia, depressive and bipolar conditions, schizophrenia and autism.
6. Helps mitochondrial respiration and gluconeogenesis. This means that it provides healthy nutrition to our cells.
7. Last but not least, being a powerful antioxidant, it helps fight free radicals that increase the likelihood of malignant tumors. The product enters the deep layers of the cell and reconstructs its structure. It is capable of creating apoptosis (i.e. destroying harmful cells). For this reason, it most likely provides protection against the development of cancer.

Resveratrol: for skin

Resveratrol rejuvenates the skin and protects against harmful environmental influences. It can be used by men and women with any skin type: it will nourish and moisturize dry skin, and soothe oily skin and relieve inflammation. But resveratrol should be used no earlier than 30-35 years, unlike natural oils: grape seed oil, Jojoba oil, avocado oil.

general characteristics

The scientific name of phytoalexin is trans-3,5,4-trans-trihydroxy-stilbene or trans-resveratrol, 3,4′,5-stilbenetriol, Resvida. The INCI classification name is Resveratrol.

In nature, resveratrol is synthesized by some plants to fight fungi, bacteria, and protect against ultraviolet radiation. According to scientists, the substance has a number of pharmacological properties: anti-inflammatory, antitumor, cardio- and neuroprotective, antioxidant, restorative, immunostimulating.

More information about resveratrol as an elixir of longevity can be obtained from the video:

Compound

Resveratrol contains many components. In nature, it has two isomeric forms:

• trans-resveratrol (glycosylated);
• cis-resveratrol (free).

The most beneficial for the body is trans-resveratrol. It is included in most supplements. Unlike cis-resveratrol, this form is highly soluble and quickly absorbed from the gastrointestinal tract. The decay period of glycosylated phytoalexin is 9 hours, and that of free phytoalexin is 10 minutes.

Trans-resveratrol is safe and has good bioavailability.

Physicochemical characteristics

Resveratrol acts as a powerful antioxidant, slowing down the rate of lipoprotein oxidation and blood cell aggregation. It also improves microcirculation and stimulates the formation of nitric oxide.

Physico-chemical characteristics:

• state – solid powder;
• color – white or straw;
• smell – nutmeg;
• melting point is 255° C, and boiling point is 449° C at an atmospheric pressure of 60 mm Hg. Art.;
• molecular weight – 228.25 g/mol;
• chemical formula – C14H12O3;
• subclass – diphenyloxide;
• category – secondary metabolites.

Photo – Structural formula of Resveratrol

According to the chemical structure, the polyphenolic compound is an aromatic polyketide.

Natural springs

Resveratrol is a natural substance. It is found in many berries and fruits. There is especially a lot of it in the skins of grapes and red wines: Cabernet Sauvignon, Red Bordeaux, Merlot, Pinot Noir.

Table - Main sources of resveratrol

There are other food sources of resveratrol, for example, cocoa (0.05 mg/100 g), dark chocolate (0.03 mg/100 g), and Japanese knotweed plant (0.15 -1.70 mg/1 g).

Resveratrol: cream

An absolute novelty in the field of cosmetics and cosmetology: face and body creams with resveratrol . Skin care products consist of natural ingredients, including concentrated resveratrol . Daily use of anti-aging creams has a good effect on the condition of the skin: it tightens, rejuvenates and becomes more elastic. It is better to choose night creams, since at night the skin is not affected by any other factors, it rests and at the same time is nourished by resveratrol .

Rating of dietary supplements

How to choose the most effective dietary supplements with resveratrol? A small rating will help you navigate the manufacturers and prices.

1. Resveratrol 250 mg with active trans-resveratrol. ReserveAge Nutrition (France). $149.09 for 120 vegetarian capsules.
2. Resveratrol Plus for atherosclerosis. Country Life (USA). $60.46 for 120 vegan capsules.
3. Tianshi. Tiens (China). $56.71 for 60 capsules.
4. Trans-resveratrol 200. Doctor's Best (USA). $45.62 for 60 vegetarian capsules.
5. Resveratrol 100 mg. Solgar (USA). $29.34 for 60 capsules.
6. Resveratrol Plant Active Extract. Paradise Herbs (USA). $23.45 for 180 vegan capsules.
7. Resveratrol Synergy. Jarrow Formulas (USA). $23.11 for 60 tablets.
8. Natural Resveratrol with green tea and grape seed extracts. Now (USA). $16.99 for 60 capsules.
9. Resveratrol. Source Naturals (USA). $14.27 for 60 tablets.
10. Resveratrol Red Wine Extract with ellagic acid and vitamin C. 21st Century (USA). $5.54 for 90 capsules.

Most of these dietary supplements can be found on IHerb, an American online store with a wide range of environmentally friendly products.

Dietary supplements with resveratrol

It is impossible to unequivocally answer the question of which brand of resveratrol is better. Each drug has its own advantages and disadvantages. The most famous manufacturers: Solgar, Tiens, Now, Doctor's Best, Paradise Herbs, Country Life, Source Naturals, 21st Century, Jarrow Formulas, ReserveAge Nutrition. The Evalar company, the Russian leader in the food additives market, is not yet producing such a drug.

On topic: Dietary supplements for weight loss

Keep in mind! David Sinclair has repeatedly become a victim of unscrupulous supplement manufacturers. Knowing the contribution he made to the study of resveratrol, they used the scientist’s name for advertising purposes, claiming that it was he who developed this drug. He had to publicly state many times that he was not doing this.

Resveratrol: and quercetin

Quercetin belongs to the group of flavonoids and has anti-inflammatory and antioxidant properties; many researchers also note its antitumor activity. Quercetin is added to various dietary supplements as an additive that enhances the active components of the drug. In the case of resveratrol , the effect is similar.
Both substances work at the cellular level and effectively fight cancer, heart disease, vascular disease, diabetes and some nervous disorders.

Resveratrol May Support Brain Health

Astrocytes are glial cells that protect neurons from damage or dysfunction. Damage to these cells occurs in many brain diseases, and the way to protect them is to remove the neurotransmitter glutamate from the synapses and the extracellular space surrounding neurons. Excess glutamate in the brain can lead to excitotoxicity and ultimately neuronal damage and even death.

In a cell model study, resveratrol increased glutamate uptake, which may improve brain protection against stroke.

In turn, in animal studies, resveratrol reduced protection in the hippocampus, the main memory center in the brain. It also increases IGF-1 (insulin-like growth factor 1) in the hippocampus, which may improve cognitive function.

In a study of brain cells, resveratrol increased the activity of the antioxidant gene heme oxygenase, which protects the brain from damage. The effect was enhanced by melatonin.

In mice with late-onset Alzheimer's disease, long-term resveratrol supplementation reduced cognitive impairment. It may also activate AMP-activated protein kinase, which maintains energy balance in the brain.

However, the effects of resveratrol on brain health have not yet been studied in clinical trials. Consequently, these benefits remain unproven.

Curcumin and resveratrol

In the scientific classification, curcumin belongs to polyphenols (in other words, part of the amino acids); this particular substance is contained in turmeric. Curcumin is believed to have anti-cancer properties. Clinical trials of curcumin-based drugs are currently underway.

Resveratrol together with curcumin have a pronounced anti-cancer effect: these two components complement each other and enhance the effect of their partner.

Release forms and contraindications

Pharmaceutical companies use various raw materials to isolate resveratrol. Most often these are grape skins and seeds, sometimes Japanese knotweed or berries are used. The pure isolated bioflavonoid is packaged in soluble capsules containing the main substance from 50 to 700 mg. Sometimes it is additionally enriched with vitamins, minerals and amino acids.

The lack of official research makes taking dietary supplements risky for pregnant and breastfeeding women. For the same reason, the drug should not be prescribed to children.

The herbal medicine should be taken with caution and only after consultation with the attending physician:

• with other antidiabetic drugs;
• non-steroidal anti-inflammatory drugs;
• anticoagulants;
• statins;
• hormones and stimulants of the endocrine system.

The dose of resveratrol is prescribed by the doctor - as a rule, no more than 200-300 mg once 3-4 times a day. Side effects and individual intolerance are rare. In some cases, allergies, diarrhea and impaired intestinal motility occur.

Resveratrol: drugs

The latest dietary supplements are created on the basis of safe and effective ingredients. Resveratrol preparations are becoming increasingly popular among the population for several reasons:

• comprehensively support the body;
• protect the cardiovascular and nervous systems;
• are good antioxidants, which in the conditions of modern ecology and the rhythm of life a person needs additional protection.

1). One of the most popular drugs is "Natural Resveratrol" from Now Foods . The package contains 120 capsules of 200 mg, the active substance is trans-resveratrol , extracted from food.

2). "Resveratrol Plus" from Country Life is recommended for people suffering from cardiovascular diseases. The enhanced formula of the drug helps even in the most advanced cases. This product contains trans-resveratrol , grape peel and seed extracts, and pine bark extract. The concentration of active components is the same as in the previous case, so you need to take the medicine once a day, 1 capsule.

Resveratrol: Solgar

3). produces excellent and high-quality resveratrol , the drug “Resveratrol” is one of them. Indications for use of this remedy: cardiovascular diseases and atherosclerosis, Alzheimer's disease, cancer and diabetes.

The package contains 60 capsules of 250 mg, based on trans-resveratrol and Sakhalin knotweed extract, the record holder for the content of pure resveratrol . You need to take 1 capsule per day with meals.

Instructions for use, price, reviews, analogues

Before you start taking biologically active components based on resveratrol, you should consult your doctor. Instructions for use may vary. The doctor can choose an individual regimen for using the drug.

Is it enough to simply eat foods rich in resveratrol?

Not really. Below we will talk more about which foods contain this useful substance. But the resveratrol content in natural products is not so high. To get the required daily dosage, you need to eat or drink a considerable amount.

For example, to get the required amount of antioxidant you will have to eat a lot of grapes. But this, in turn, can harm the body. After all, grapes are rich in fructose, and its excessive amount leads to problems associated with metabolic disorders.

What are the recommendations for using supplements? They may differ depending on the original raw material from which the extract was isolated and on the form of release of the drug.

Resveratrol - instructions for use

Pharmaceutical manufacturers use a variety of raw materials to isolate resveratrol. Most often, bioflavonoid extract is obtained from the peel and seeds of grapes or berries. Soluble capsules usually contain from 50 to 700 mg of the main substance. In addition to resveratrol, preparations can additionally be enriched with vitamins, minerals and amino acids.

The optimal dosage is 200-300 mg up to 4 times a day. However, it has been proven that consuming doses up to 5000 mg per day is safe.

The instructions contain indications for the use of drugs with a high content of resveratrol:

• High levels of stress and mental stress, treatment of neuroses, depressive disorders.
• Intense sports training.
• The period of active recovery after injuries and surgeries, as well as after heart attacks and strokes.
• Severe chronic diseases such as oncology, diabetes, autoimmune diseases, HIV. Diseases affecting a person's quality of life.
• Complex therapy of hypertension, atherosclerosis, gastric ulcer, hepatitis, parasitic infestations.
• Living and working in environmentally polluted areas.
• Elderly age.
• Pregnancy planning and preparation for the IVF procedure.

Analogs

Vitamin complexes and biological substances with antioxidant and immunomodulatory properties have a similar effect. Some drugs include:

1. Ancarcin. Adaptogenic antioxidant complex, which is used in the treatment of autoimmune diseases and as an oncoprotective agent.
2. Oxyvital. Complex of vitamins with selenium. Increases immunity, improves performance and active brain activity.
3. Viteroy. Vitaminized plant complex with royal jelly of bees. Increases immunity, reduces blood sugar.

Resveratrol: analogues

1). As an alternative analogue to resveratrol, you can choose Natrol AcaiBerry, The Ultimate Super Fruit. The package contains 75 capsules at a dosage of 1000 mg, containing pure acai berry extract. Acai berries are a powerful antioxidant that reduces free radical activity more effectively than other similar drugs. This magical berry is also very nutritious, it contains vitamin C, vitamin E, vitamin B1, vitamin B2, which are essential for health. You need to take the drug 2 times a day with meals in courses every other month.

2). “Antioxidant Superfood” from FutureBiotics is one of the most delicious preparations with an antioxidant effect, because it contains a wide variety of berries and fruits: exotic mangosteen, green tea extract, grape seed extract, grapefruit, apple, blueberry, cranberry, plum, raspberry, There's even ginger root! This drug will not only take care of protecting the body from harmful free radicals, but will also support the nervous system. It is produced in a concentration of 1000 mg, in a package of 90 capsules, which should be taken 3 per day before meals (i.e., 1 capsule per meal).

3). And finally, another effective drug “Glutathione” from Now Foods . Glutathione is a natural antioxidant for humans; it is produced independently by the body from essential amino acids. Glutathione acts primarily in immune cells, increasing their resistance to various viruses and bacteria. This drug is enhanced with milk thistle extract and alpha-lipoic acid, which are famous for their antioxidant and immunostimulating effects. The dietary supplement is available in a concentration of 600 mg; you need to take 3 capsules a day, preferably before meals, of course, not forgetting to take breaks every month.

The principle of action of resveratrol on the body

This substance has very beneficial properties for human health and acts on the body with such effects as:

• rejuvenating;
• antibacterial;
• anti-inflammatory;
• anti-cancer.

Resveratrol has undergone many different studies in scientific laboratories.

The experiments were carried out for a long time, and the experimental subjects were not only mice and rats, but also people who gave consent to these studies.

Experimentally, it was possible to find out that polyphenol, which plays the role of an antioxidant, not only prevents the development of free radicals, but destroys them. This happens even when free radicals have already firmly established themselves in the body and have begun their destructive effect on cell membranes.

It is thanks to this unique ability that antioxidants are very important substances for the human body - they can improve overall physical condition, rejuvenate and improve health.

Resveratrol is the most powerful and powerful plant antioxidant, which is more active than vitamin E - 50 times, beta-carotene - 5 times, vitamin C - 20 times.

Resveratrol: buy, price

Here is such a large assortment of forms, dosages and manufacturers of resveratrol :

Buy capsules, tablets and liquid Resveratrol!

1. You can buy resveratrol at a low price and with guaranteed high quality in the famous American online organic store iHerb. 2. Detailed instructions for placing an order: How to place an order on iHerb! 3. When ordering using an iHerb promotional code, you have access to a 5% discount on ANY order (without ADDITIONAL DISCOUNTS), as well as profitable Promotions of up to 40%! We definitely recommend using it, because... on the second order there may no longer be such a big discount, and even the best cashback services will not always return interest on the purchase, because the prices are very low! We have also prepared for you a Svyaznoy promotional code for communications and devices, Krasotka Pro coupons for varnishes and tools, Citylink promotional codes for laptop components, Techport promotional code for equipment and furniture! Here you can find discounts on all types of goods! 4. All about payment and delivery: iHerb payment and iHerb delivery!

Photo source: iHerb.com

Best before date

24 months

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The description of Vitamin Natural Resveratrol is intended for informational purposes only. Before starting to use any drug, it is recommended to consult a doctor and read the instructions for use. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the project does not replace consultation with a specialist and cannot be a guarantee of the positive effect of the drug you use. The opinions of EUROLAB portal users may not coincide with the opinions of the site Administration.

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Patient reviews

Consumers use Resveratrol for the following purposes:

• to reduce joint pain;
• to relieve pain in the head area if the patient has vegetative-vascular dystonia;
• for the treatment of thrombophlebitis;
• as a means to reduce appetite;
• to improve your ability to work;
• to improve sleep.

From a theoretical point of view, the purpose of Resveratrol is to protect the heart and provide antioxidants, but this effect cannot be appreciated by consumers. But judging by their reviews, thanks to this substance, pain of various kinds was reduced.

It is noted that this is a very good natural product that helps you feel more energetic and active, your overall physical condition improves, and your stamina increases. In addition, the substance helps muscles and joints, cleanses the face, and reduces sugar content. Thanks to it, you can also get rid of not only extra pounds, but also depression.

Elderly patients note that the use of capsules, coupled with eating organic food and superfoods, and practicing yoga, leads to the fact that even in old age they do not take any medications. Resveratrol is an important component in the arsenal of patients struggling for their health.

Safety and side effects

Resveratrol taken in doses up to 500 mg/day is well tolerated, as proven by many clinical studies in healthy people.

High doses of highly bioavailable resveratrol (up to 5 g/day) given to metastatic cancer patients did not cause any serious side effects. Some patients, however, experienced nausea and stomach upset ().

In children

Resveratrol is probably safe for children (over 5 years of age) ().

During pregnancy

It has been suggested that resveratrol is beneficial during pregnancy for metabolic balance and prenatal health. No clinical studies have examined resveratrol in pregnant women. Taking resveratrol from food is likely safe, but supplements should be avoided due to a lack of safety data.

In one study of monkeys fed a resveratrol-rich diet throughout pregnancy, resveratrol had both good and bad effects ():

• It reduced weight gain during pregnancy, improved glucose tolerance, increased blood flow to the fetus, and reduced inflammation of the placenta and liver.
• However, it enlarged the fetal pancreas by about 40% and caused excessive cell division in the fetal pancreas.

Overall, it seems to benefit the mother, but may be harmful to the baby. Its effect on the fetal pancreas is a serious cause for concern.

Protecting Cognition and Brain

According to doctors, resveratrol (we explained what it is) stimulates brain function. Its molecules are able to overcome the blood barrier in the brain and affect both the brain itself and the nervous system. Research conducted recently in the UK, at Northumbria University, showed that thanks to resveratrol, blood flow to the brain increases, resulting in a positive effect on its functioning. Thus, by eating foods containing excess resveratrol, you can protect yourself from Alzheimer's disease. Scientists have proven that even in minimal dosage it has a significant effect on brain protection.